期刊
JOURNAL OF VIROLOGY
卷 79, 期 15, 页码 10053-10058出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.79.15.10053-10058.2005
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- NHGRI NIH HHS [P50 HG002360] Funding Source: Medline
- NIAID NIH HHS [R21 AI52028, R01 AI058894] Funding Source: Medline
Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays. HIV-1 increased gene expression of cholesterol genes in both transformed T-cell lines and primary CD4(+) T cells. Consistent with our microarray data, C-14-labeled mevalonate and acetate incorporation was increased in HIV-1-infected cells. Our data also demonstrate that changes in cholesterol biosynthesis and uptake are only observed in the presence of functional Nef, suggesting that increased cholesterol synthesis may contribute to Nef-mediated enhancement of virion infectivity and viral replication.
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