期刊
EUROPEAN JOURNAL OF CANCER
卷 41, 期 12, 页码 1767-1774出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ejca.2005.02.036
关键词
late effects; neuroblastoma; I-131-MIBG; chemotherapy; hypogonadism; hypothyroidism; thyroid nodules; growth retardation; childhood cancer survivors
类别
Thyroid dysfunction has been reported after I-131-MIBG-treatment for neuroblastoma. In this study, we have evaluated all endocrine functions from patients who were given multi-modality treatment including I-131-MIBG. Twenty-five neuroblastoma survivors who were off therapy for a median period of 6.0 years (range 1.3-11.1) were evaluated and their median age was 8.1 years (range 2.2-14.7). All patients had received I-131-MIBG, 16 chemotherapy, and 16 surgery. Fourteen patients (56%) had permanently elevated thyrotropin levels and 9 received thyroxine. Two patients had a small thyroid volume while 6 had thyroid nodules or cysts. Two boys showed hypergonadotropic hypogonadism. Growth was retarded in 39% of children. Mean Target Height Standard Deviation Score of patients with thyrotropin elevation was lower than those without (P=0.019). Children treated for neuroblastoma with I-131-MIBG, chemotherapy and surgery were seen to be at risk from developing irreversible thyroid function loss, thyroid nodules, hypergonadotropic hypogonadism, and growth retardation. We recommend that during follow-up of neuroblastoma children, special attention should be paid to their endocrine state. (C) 2005 Elsevier Ltd. All rights reserved.
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