期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 15, 期 4, 页码 447-452出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2005.06.004
关键词
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资金
- NIGMS NIH HHS [GM 068664-01] Funding Source: Medline
Directed evolution is a common technique to engineer enzymes for a diverse set of applications. Structural information and an understanding of how proteins respond to mutation and recombination are being used to develop improved directed evolution strategies by increasing the probability that mutant sequences have the desired properties. Strategies that target mutagenesis to particular regions of a protein or use recombination to introduce large sequence changes can complement full-gene random mutagenesis and pave the way to achieving ever more ambitious enzyme engineering goals.
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