期刊
JOURNAL OF MOLECULAR EVOLUTION
卷 61, 期 2, 页码 264-273出版社
SPRINGER
DOI: 10.1007/s00239-004-0362-7
关键词
RNA world; miniribozymes; RNA evolution; freezing catalysis
The RNA world hypothesis refers to a hypothetical era prior to coded peptide synthesis, where RNA was the major structural, genetic, and catalytic agent. Though it is a widely accepted scenario, a number of vexing difficulties remain. In this review we focus on a missing link of the RNA world hypothesis-primitive miniribozymes, in particular ligases, and discuss the role of these molecules in the evolution of RNA size and complexity. We argue that prebiotic conditions associated with freezing, rather than warm and wet conditions, could have been of key importance in the early RNA world.
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