期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 45, 期 2, 页码 303-310出版社
WILEY-BLACKWELL
DOI: 10.1016/j.femsim.2005.05.007
关键词
tuberculosis; CpG; macrophages
Immunostimulatory DNA sequences and their synthetic oligonucleotide analogs (CpG-ODN) activate innate immunity and can stimulate antibacterial effects against numerous intracellular pathogens. While it has been shown previously that CpG-ODN inhibit growth of Mycobacterium avium in murine and human macrophages, we now report that Mycobacterium tuberculosis growth can be inhibited by CpG-ODN treatment of human monocyte-derived macrophages (hMDM). This inhibitory effect was reversed by IFN-gamma, which has been shown repeatedly to enhance the growth of virulent M. tuberculosis in cultured hMDM. The antibacterial effect of CpG-ODN in human macrophages was specific for M. tuberculosis when compared to other intracellular pathogens including Listeria monocytogenes and Salmonella enterica serovar Dublin. These data indicate that CpG-ODN can improve the ability of hMDM to contain growth of virulent M. tuberculosis. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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