期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 6, 期 8, 页码 599-609出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1700
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Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used for many other purposes. Furthermore, there are many ubiquitin-like proteins that control the activities of proteins. The central structural element of these post-translational modifications is the ubiquitin superfold. A common ancestor based on this superfold has evolved to give various proteins that are involved in diverse activities in the cell.
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