期刊
SEMINARS IN IMMUNOLOGY
卷 17, 期 4, 页码 304-312出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2005.05.001
关键词
thymus; dendritic cell; plasmacytoid dendritic cell; dendritic cell development; thymocyte selection
类别
Thymus is the site of generation and selection of T-lymphocytes. It also contains phenotypically and functionally distinct dendritic cell (DC) populations, including conventional DC (cDC) and plasmacytoid DC (pDC). Thymic cDC are heterogeneous and contain two subsets: a major subset derived from the precursors within thymus, and a minor subset presumably of extrathymic origin. Increasing evidence suggest that thymic cDC can cross-present self-antigens to developing thymocytes and play an important role in thymocyte negative selection and central tolerance induction. Thymic pDC can produce type-1 interferon upon appropriate activation. However, their role in a steady state thymus is currently unclear. (c) 2005 Elsevier Ltd. All rights reserved.
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