期刊
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
卷 289, 期 2, 页码 C483-C492出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00547.2004
关键词
amphipathic tastants; tastant permeation; desensitization; lingering aftertaste
Sweet and bitter taste sensations are believed to be initiated by the tastant-stimulated T1R and T2R G protein-coupled receptor ( GPCR) subfamilies, respectively, which occur in taste cells. Although such tastants, with their significantly diverse chemical structures ( e. g., sugar and nonsugar sweeteners), may share the same or similar T1Rs, some nonsugar sweeteners and many bitter tastants are amphipathic and produce a significant delay in taste termination ( lingering aftertaste). We report that such tastants may permeate rat taste bud cells rapidly in vivo and inhibit known signal termination-related kinases in vitro, such as GPCR kinase (GRK) 2, GRK5, and PKA. GRK5 and perhaps GRK2 and GRK6 are present in taste cells. A new hypothesis is proposed in which membrane-permeant tastants not only interact with taste GPCRs but also interact intracellularly with the receptors' downstream shutoff components to inhibit signal termination.
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