期刊
FEBS LETTERS
卷 579, 期 19, 页码 4076-4080出版社
WILEY
DOI: 10.1016/j.febslet.2005.06.033
关键词
farnesoid X receptor; fasting; PEPCK; gluconeogenesis
The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transient lower in FXR(-/-)mice after 6 h of fasting and was decreased in FXR(-/-)hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据