期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 70, 期 16, 页码 6515-6518出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo050671l
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资金
- NIGMS NIH HHS [P50 GM069663] Funding Source: Medline
Electrophilic palladium-catalyzed cycloisomerization of brominated aryl propiolates produces brominated coumarins. The brominated cournarins can be diversified by reduction of the Pd(II) catalyst to Pd(O) followed by Suzuki, Sonogashira, Heck, or Hartwig-Buchwald coupling. Thus, a single loading of precatalyst can be used to conduct sequential reactions, allowing the synthesis of functionalized coumarins. Extension of this methodology toward the synthesis of coumarin libraries is discussed.
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