期刊
DEVELOPMENTAL BRAIN RESEARCH
卷 158, 期 1-2, 页码 102-106出版社
ELSEVIER
DOI: 10.1016/j.devbrainres.2005.05.002
关键词
development and regeneration; patterns, compartments, and boundaries; EphB; ephrin-A; optic tectum development; retinotopic mapping; gene expression
Eph/ephrin expression was studied in Rana utricularia larvae and adults with in situ receptor and ligand affinity probes. From stages TK-II (early limb bud) to VI (early foot paddle larva), tectal EphB expression is highest in a band extending transversely across the posterior optic tectum and grades off anteriorly and posteriorly. The ephrin-A expression gradient is parallel to the EphB gradient rather than being orthogonal to it. However, its, high point occupies the posterior pole, and it runs from high-posteriorly to low-anteriorly. Tectal EphA expression is high anteriorly and low posteriorly, while ephrin-Bs are expressed only in a thin line at the dorsal midline. At later stages and in adults, tectal EphB expression becomes uniform. (c) 2005 Elsevier B.V. All rights reserved.
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