期刊
DEVELOPMENTAL BRAIN RESEARCH
卷 158, 期 1-2, 页码 111-114出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.devbrainres.2005.06.005
关键词
neurotransmitters, modulators, transporters and receptors; GABA receptors; Drosophila melanogaster; gamma-aminobutyric acid (GABA); GABA(B) receptor; development
Previously, an RNA interference (RNAi) knockdown of GABA(B(1)) subunit in adult Drosophila was used for behavioral studies. Here we report on developmental deficits caused by embryonic Drosophila GABA(B(1)) RNAi and drug antagonism. Injecting embryos with CGP54626 (a GABA(B) receptor antagonist) reduced hatching and caused lethality. Similar effects were produced by injecting embryos with GABA(B(1)) double-stranded RNA (RNAi). The surviving GABA(B(1)) RNAi larvae were significantly smaller than controls and showed a peculiar phenotype; their tracheae were folded. Our results suggest that GABA(B) receptors are required for normal development and that the Drosophila model could be used to investigate the participating molecular mechanisms. (c) 2005 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据