期刊
BIOCHEMISTRY
卷 44, 期 31, 页码 10696-10701出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi050436x
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资金
- NCI NIH HHS [CA96504] Funding Source: Medline
We have used directed evolution to construct IL-2 mutants that bind the IL-2 a receptor subunit (IL-2R alpha, CD25) with affinities comparable to that of the IL-15-IL-15 a receptor subunit (IL-15R alpha) interaction. T cells proliferate for up to 6 days following a 30 minute incubation with these IL-2 mutants, which may lead to potential applications for cancer and viral immunotherapy. Several alternative mechanisms have been proposed to explain the contrasting effects of IL-2 and IL-15 on T cell proliferation and death. These IL-2 mutants exhibit T cell growth response-receptor occupancy curves indistinguishable from that for IL-15, suggesting that much of the difference between wild-type IL-2 and IL-15 effects arises simply from their 1000-fold differing affinities for their private a receptor subunits.
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