期刊
SCIENCE
卷 309, 期 5737, 页码 1071-1073出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1111410
关键词
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资金
- NICHD NIH HHS [T32 HD007502] Funding Source: Medline
- NIGMS NIH HHS [GM 069875, R01 GM069875] Funding Source: Medline
Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.
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