期刊
CELL
卷 122, 期 3, 页码 379-391出版社
CELL PRESS
DOI: 10.1016/j.cell.2005.06.015
关键词
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资金
- NCRR NIH HHS [UL1 RR025764] Funding Source: Medline
- NHLBI NIH HHS [HL-75507, HL-66277, R01 HL066277, HL-62875, R01 HL062875, R37 HL044525, HL-44525, R01 HL044513, R01 HL044525, R01 HL075507, HL-44513] Funding Source: Medline
- NICHD NIH HHS [R01 HD054599] Funding Source: Medline
Platelets are specialized hemostatic cells that circulate in the blood as anucleate cytoplasts. We report that platelets unexpectedly possess a functional spliceosome, a complex that processes pre-mRNAs in the nuclei of other cell types. Spliceosome components are present in the cytoplasm of human megakaryocytes and in proplatelets that extend from megakaryocytes. Primary human platelets also contain essential spliceosome factors including small nuclear RNAs, splicing proteins, and endogenous pre-mRNAs. In response to integrin engagement and surface receptor activation, platelets precisely excise introns from interleukin-1 beta pre-mRNA, yielding a mature message that is translated into protein. Signal-dependent splicing is a novel function of platelets that demonstrates remarkable specialization in the regulatory repertoire of this anucleate cell. While this mechanism may be unique to platelets, it also suggests previously unrecognized diversity regarding the functional roles of the spliceosome in eukaryotic cells.
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