期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 202, 期 4, 页码 461-465出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20051395
关键词
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Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique molecular mechanisms underlying the remarkably rapid and efficient type I IFN production by pDCs.
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