期刊
IMMUNOLOGY LETTERS
卷 100, 期 1, 页码 88-93出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2005.06.011
关键词
antibodies; serology; thymidylate synthase (TYMS); 5-fluorouracil (5-FU)
类别
资金
- NCI NIH HHS [N01 CO 12400] Funding Source: Medline
Thymidylate synthase (TYMS), the critical enzyme for DNA synthesis and a target for chemotherapy, was recently characterized as an oncogene and a potential target for specific immunotherapy. Here we report TYMS-specific antibody response in a fraction of colon cancer patients. Humoral immune response to TYMS is induced by chemotherapy using TYMS inhibitors, such as 5-fluorouracil (5-FU), and may be associated with tumor burden. Therefore, TYMS may serve as a useful serological biomarker for monitoring the course of disease and treatment in cancer patients. (c) 2005 Elsevier B.V. All rights reserved.
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