期刊
FEBS LETTERS
卷 579, 期 20, 页码 4437-4442出版社
WILEY
DOI: 10.1016/j.febslet.2005.07.008
关键词
plant mitochondria; uncoupling protein activity; inhibition by GTP; ubiquinone
In isolated potato tuber mitochondria, palmitic acid (PA) can induce a H+ leak inhibited by GTP in the phosphorylating (state 3) respiration but not in the resting (state 4) respiration. The PA-induced H+ leak is constant when state 3 respiration is decreased by an inhibition of the succinate uptake with n-butyl malonate (nBM). We show that the efficiency of inhibition by GTP is decreased when state 3 respiration is progressively inhibited by antimycin A (AA) and is restored following subsequent addition of nBM. We propose that in phosphorylating potato tuber mitochondria, the redox state of ubiquinone, which can antagonistically be varied with AA and nBM, modulates inhibition of the PA-activated UCP-sustained H+ leak by GTP. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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