期刊
NEURON
卷 47, 期 4, 页码 503-513出版社
CELL PRESS
DOI: 10.1016/j.neuron.2005.06.031
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资金
- NCRR NIH HHS [RR00165] Funding Source: Medline
- NIMH NIH HHS [MH070112, MH56897, MH056538, MH64692] Funding Source: Medline
Vasopressin modulates many social and nonsocial behaviors, including emotionality. We have previously reported that male mice with a null mutation in the V1a receptor (V1aR) exhibit a profound impairment in social recognition and changes in anxiety-like behavior. Using site-specific injections of a V1aR-specific antagonist, we demonstrate that the lateral septum, but not the medial amygdala, is critical for social recognition. Reexpressing V1aR in the lateral septum of V1aR knockout mice (V1aRKO) using a viral vector resulted in a complete rescue of social recognition. Furthermore, overexpression of the V1aR in the lateral septum of wild-type (wt) mice resulted in a potentiation of social recognition behavior and a mild increase in anxiety-related behavior. These results demonstrate that the V1aR in the lateral septum plays a critical role in the neural processing of social stimuli required for complex social behavior.
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