期刊
SYNLETT
卷 -, 期 13, 页码 2077-2079出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-871953
关键词
kavain; total synthesis; (MeCN)(2)PdCl2-catalyzed; isomerization; cis double bond; sonochemical Blaise reaction
From the chiral source 2,3-O-isopropylidene-D-glyceraldehyde 2, the natural product (R)-(+)-kavain 1a was efficiently synthesized in a total yield of 25% via (MeCN)(2)PdCl2-catalyzed isomerization of the cis double bond of an olefin as the key step and sonochemical Blaise reaction. The chiral center adjacent to the cis double bond was retained without protection of the free allylic hydroxy during the isomerization process.
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