期刊
SCIENCE
卷 309, 期 5738, 页码 1245-1248出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1115109
关键词
-
资金
- NIAID NIH HHS [AI23348] Funding Source: Medline
Bacteria have developed mechanisms to communicate and compete with each other for Limited environmental resources. We found that certain Escherichia coli, including uropathogenic strains, contained. a bacterial growth-inhibition system that uses direct cell-to-cell contact. Inhibition was conditional, dependent upon the growth state of the inhibitory cell and the pili expression state of the target cell. Both a large cell-surface protein designated Contact-dependent inhibitor A (CdiA) and two-partner secretion family member CdiB were required for growth inhibition. The CdiAB system may function to regulate the growth of specific cells within a differentiated bacterial population.
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