期刊
NEUROREPORT
卷 16, 期 12, 页码 1285-1290出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wnr.0000176515.11723.a2
关键词
cerebellum; prenatal alcohol exposure; structural magnetic resonance imaging; verbal learning and memory
资金
- NCRR NIH HHS [P41 RR13642] Funding Source: Medline
- NIAAA NIH HHS [AA 10417, U24 AA014808, AA 10820] Funding Source: Medline
- NIDA NIH HHS [R01 DA 017831, DA 015875] Funding Source: Medline
- NIMH NIH HHS [K01 MH01733] Funding Source: Medline
- NINDS NIH HHS [NS3753] Funding Source: Medline
Prenatal exposure to alcohol can result in neuroanatomical and neurocognitive deficits. High-resolution magnetic resonance imaging, surface-based image analytic methods, and neuropsychological measures were used to characterize the cerebellar vermis and to evaluate potential cognitive correlates of vermal morphology in 21 children and adolescents with prenatal alcohol exposure and 21 normally developing individuals. Alcohol-exposed individuals showed statistically significant reductions in the midline sagittal areas of the anterior vermis and posterior-inferior vermis, and significant displacement of the anterior and posterior-inferior vermal regions. Anterior vermal dysmorphology was negatively correlated with verbal learning and memory performance within the alcohol-exposed group. These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the specific pattern of cerebellar vermal dysmorphology.
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