期刊
BRITISH JOURNAL OF CANCER
卷 93, 期 4, 页码 453-457出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602715
关键词
osteopontin (OPN); non-small-cell lung cancer (NSCLC); immunohistochemistry (IHC); disease-free survival; overall survival
类别
Osteopontin (OPN) is a multifunctional protein, which has recently been shown to be linked to tumorigenesis, progression and metastasis in different malignancies. Since non-small-cell lung cancer (NSCLC)' s prognosis remains bad, with few predictors of outcome, the purpose of this study was to evaluate if OPN might be involved in NSCLC's biology and therefore represent a prognostic marker and a target for new therapeutic trials. Immunohistochemistry was used to detect OPN expression, evaluated as percentage of neoplastic cells with cytoplasmic immunoreactivity, in a wide cohort of patients with stage I NSCLC ( 136 cases). The median value of this series (20% of positive cells) was used as the cutoff value to distinguish tumours with low (<20%) from tumours with high (>= 20%) OPN expression. A statistically significant correlation between high levels of OPN and shorter overall ( P = 0.034) and disease-free ( P = 0.011) survival in our patients was shown. Our results support the hypothesis that high OPN expression is a significantly unfavourable prognostic factor for the survival of patients with stage I NSCLC. This conclusion has notable importance in terms of the biological characterization of early-stage tumours and therapeutic opportunities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据