期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 48, 期 17, 页码 5408-5411出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm050113z
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资金
- NIGMS NIH HHS [GM58114] Funding Source: Medline
We report that N-6-(1-naphthyl)-ADP (1) inhibits the Escherichia coli RecA protein in vitro. A novel rapid screen identified 1 as a potent inhibitor of RecA nucleoprotein filament formation, and further characterization established 1 as an ATP-competitive inhibitor of RecA-catalyzed ATP hydrolysis. 1 and other inhibitors of RecA activities represent a new approach for understanding the molecular targets and pathways involved in the evolution of antibiotic resistance in bacteria.
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