期刊
SCIENCE
卷 309, 期 5739, 页码 1373-1376出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1115964
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During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-beta. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle.
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