期刊
FEBS LETTERS
卷 579, 期 21, 页码 4851-4855出版社
WILEY
DOI: 10.1016/j.febslet.2005.07.066
关键词
coeliac; barrier function; tight junction; adherens junction; permeability
Coeliac disease is a chronic enteropathy caused by the ingestion of wheat gliadin and other cereal prolamines derived from rye and barley. In the present work, we investigated the mechanisms underlying altered barrier function properties exerted by gliadin-derived peptides in human Caco-2 intestinal epithelial cells. We demonstrate that gliadin alters barrier function almost immediately by decreasing transepithelial resistance and increasing permeability to small molecules (4 kDa). Gliadin caused a reorganisation of actin filaments and altered expression of the tight junction proteins occludin, claudin-3 and claudin-4, the TJ-associated protein ZO-1 and the adherens junction protein E-cadherin. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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