期刊
FEBS LETTERS
卷 579, 期 21, 页码 4629-4634出版社
WILEY
DOI: 10.1016/j.febslet.2005.07.031
关键词
yeaS; RhtB family; Lrp; primer extension; yeaT; Escherichia coli
Overexpression of the yeaS gene encoding a protein belonging to the RhtB transporter family conferred upon cells resistance to glycyl-L-leucine, leucine analogues, several amino acids and their analogues. yeaS overexpression promoted leucine and, to a lesser extent, methionine and histidine accumulation by the respective producing strains. Our results indicate that yeaS encodes an exporter of leucine and some other structurally unrelated amino acids. The expression of yeaS (renamed leuE for leucine export) was induced by leucine, L-alpha-amino-n-butyric acid and, to a lesser extent, by several other amino acids. The global regulator Lrp mediated this induction. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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