期刊
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
卷 12, 期 3, 页码 123-131出版社
SPRINGER
DOI: 10.1207/s15327558ijbm1203_1
关键词
psychoneuroimmunology; socioeconomic status; stress buffering; social integration; social rank; social support; infectious illness susceptibility; respiratory infections; common cold; influenza; cytokine regulation; cortisol regulation
资金
- U.S. National Institute of Allergies and Infectious Diseases [AI23072]
- U.S. National Institute of Mental Health [NIMH: MH47234, MH50429]
- NIMH [MH00721]
- John D. and Catherine T. MacArthur Foundation Network on Socioeconomic Status and Health
- Pittsburgh NIH Mind-Body Center [HL65111, HL65112]
This article provides a selected overview of 20 years of research on the role of psychosocial factors in susceptibility to upper respiratory infections. We present evidence from our laboratory that psychological stress is associated with increased risk for developing respiratory illness for persons intentionally exposed to a common cold virus, that the longer the duration of the stressor the greater the risk, and that stress association with susceptibility may be mediated by stress-induced disruption of the regulation of proinflammatory cytokines. We further provide evidence that social relationships (social integration and social support) are also associated with risk for respiratory illness: Social integration is associated with reduced risk irrespective of stress level and social support protects persons from the pathogenic influences of stress. Finally, we report recent evidence that lower levels of early childhood socio-economic status (SES) are associated with greater risk of viral-induced illness during adulthood, independent of adult SES.
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