期刊
APOPTOSIS
卷 20, 期 2, 页码 216-223出版社
SPRINGER
DOI: 10.1007/s10495-014-1068-y
关键词
Death receptor; Bacterial pathogens; T3SS effectors; NF-kappa B; Programmed cell death
资金
- National Natural Science Foundation of China (NSFC) [31470245]
Death receptors such as Tumor necrosis factor receptor 1, FAS and TNF-associated apoptosis-inducing ligand-R1/2 play a major role in counteracting with bacterial pathogen infection through regulation of inflammation and programmed cell death. The highly regulated death receptor signaling is frequently targeted by gram-negative bacterial pathogens such as Salmonella, Shigella, enteropathogenic Escherichia coli and enterohamorrhagic Escherichia coli, which harbor a conserved type III secretion system that delivers a repertoire of effector proteins to manipulate host signal transductions for their own benefit. This review focuses on how bacterial gut pathogens hijack death receptor signaling to inhibit host NF-kappa B and programmed cell death pathways.
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