4.7 Article

Mutations associated with Sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi

期刊

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 49, 期 9, 页码 3919-3921

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AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.49.9.3919-3921.2005

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资金

  1. NIAID NIH HHS [R01 AI049084] Funding Source: Medline
  2. NICHD NIH HHS [1U01 HD043475, U01 HD043475] Funding Source: Medline

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We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found.

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