期刊
NATURE GENETICS
卷 37, 期 9, 页码 980-985出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1622
关键词
-
资金
- NICHD NIH HHS [R01 HD043173] Funding Source: Medline
- NIDCD NIH HHS [R01 DC004709, R01 DC005213] Funding Source: Medline
- NINDS NIH HHS [R01 NS073159] Funding Source: Medline
The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with uniformly oriented stereocilia on the apical surfaces and has a distinct planar cell polarity ( PCP) parallel to the sensory epithelium(1-3). It is not certain how this polarity is achieved during differentiation(4,5). Here we show that the organ of Corti is formed from a thicker and shorter postmitotic primordium through unidirectional extension, characteristic of cellular intercalation known as convergent extension(6). Mutations in the PCP pathway interfere with this extension, resulting a shorter and wider cochlea as well as misorientation of stereocilia. Furthermore, parallel to the homologous pathway in Drosophila melanogaster(7,8), a mammalian PCP component Dishevelled2 shows PCPdependent polarized subcellular localization across the organ of Corti. Taken together, these data suggest that there is a conserved molecular mechanism for PCP pathways in invertebrates and vertebrates and indicate that the mammalian PCP pathway might directly couple cellular intercalations to PCP establishment in the cochlea.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据