期刊
JOURNAL OF MEMBRANE BIOLOGY
卷 207, 期 1, 页码 35-43出版社
SPRINGER
DOI: 10.1007/s00232-005-0801-4
关键词
patch clamp; persistent currents; quantitative modeling
State-dependent blockade of human cardiac hNav1.5 sodium channels by propafenone was studied using whole-cell patch clamp techniques. Both a direct investigation using cells with inactivation-deficient sodium channels and an algorithmic approach used on cells with wild-type channels revealed a rapid binding of propafenone to the open state. This occurs approximately 4000 and 700 times faster than the binding to the resting and inactivated state, respectively. An established mathematical gating model was modified to represent the experimental data.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据