Nevirapine plasma exposure affects both durability of viral suppression and selection of Nevirapine primary resistance mutations in a clinical setting

The relationship between nevirapine plasma concentrations and the durability of both viral suppression (VS) and selection of nevirapine primary resistance mutations (PRMs) was evaluated. A nevirapine trough concentration (C-trough) of > 4,300 ng/ml was found to predict longer VS. Patients with nevirapine C(trough)s ranging from 3,100 to 4,300 ng/ml had higher probabilities of developing PRMs than those with nevirapine Ctroughs below and above this concentration interval.