期刊
BIOCHEMISTRY-MOSCOW
卷 70, 期 9, 页码 1065-1069出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1007/s10541-005-0225-x
关键词
T-cells; transcription factor GATA-3; interleukin-4; promoter; repressor
GATA-3 was shown to bind to two sites of the IL-4 gene promoter in human T-cell lines PER-I 17 and Jurkat. A motif located in the region of position -860 and responsible for GATA-3 binding was detected for the first time. Mutation or deletion of this site increased the promoter activity. The findings suggest a direct involvement of GATA-3 in regulation of the human IL-4 gene transcription as a repressor of the promoter activity.
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