期刊
APOPTOSIS
卷 13, 期 7, 页码 904-914出版社
SPRINGER
DOI: 10.1007/s10495-008-0221-x
关键词
endoplasmic reticulum; curcumin; ER stress; caspase; apoptosis; programmed cell death
资金
- NIA NIH HHS [R01 AG012282-06, R01 AG012282-09, R01 AG012282-10, AG12282, R01 AG012282-11, R01 AG012282, R01 AG012282-08, R01 AG012282-07A1, R01 AG012282-07A1S1] Funding Source: Medline
- NINDS NIH HHS [R01 NS045093-05, R01 NS033376-06, R01 NS033376-07, R01 NS033376-08, R01 NS045093-01, R01 NS045093-04, R01 NS033376-04, R01 NS033376, R01 NS033376-10, NS33376, R01 NS045093-02, R01 NS045093, R01 NS033376-05, R01 NS033376-09, R01 NS045093-03, NS45093] Funding Source: Medline
The microenvironment of cancerous cells includes endoplasmic reticulum ( ER) stress the resistance to which is required for the survival and growth of tumors. Acute ER stress triggers the induction of a family of ER stress proteins that promotes survival and/or growth of the cancer cells, and also confers resistance to radiation and chemotherapy. Prolonged or severe ER stress, however, may ultimately overwhelm the cellular protective mechanisms, triggering cell death through specific programmed cell death (pcd) pathways. Thus, downregulation of the protective stress proteins may offer a new therapeutic approach to cancer treatment. In this regard, recent reports have demonstrated the roles of the phytochemical curcumin in the inhibition of proteasomal activity and triggering the accumulation of cytosolic Ca2+ by inhibiting the Ca2+-ATPase pump, both of which enhance ER stress. Using a mouse melanoma cell line, we investigated the possibility that curcumin may trigger ER stress leading to programmed cell death. Our studies demonstrate that curcumin triggers ER stress and the activation of specific cell death pathways that feature caspase cleavage and activation, p23 cleavage, and downregulation of the anti-apoptotic Mc1-1 protein.
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