期刊
NATURE CELL BIOLOGY
卷 7, 期 9, 页码 847-849出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0905-847
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In the course of an investigation aimed at characterizing hepatic glucose 6- phosphatase, the unrelated acid phosphatase of rat liver was serendipitously observed to be latent and particle- bound in freshly prepared homogenates. Experiments designed to elucidate this intriguing finding led, 50 years ago, to the discovery of lysosomes. This could not have happened if strict adherence to a previously set programme had been mandatory.
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