期刊
CHEST
卷 128, 期 3, 页码 1324-1330出版社
ELSEVIER
DOI: 10.1378/chest.128.3.1324
关键词
breathing; computational model; lung; MRI; obstructive sleep apnea; pharyngeal collapse
资金
- NHLBI NIH HHS [R01 HL48531, P50 HL060292, R01 HL073146, R01 HL048531, HL60292, R01 HL073146-02] Funding Source: Medline
- NIA NIH HHS [AG024837-01, K23 AG024837-03, K23 AG024837] Funding Source: Medline
Obstructive sleep apnea (OSA) is a common disease with important neurocognitive and cardiovascular sequelae. Existing therapies are unsatisfactory, leading investigators to seek alternative forms of anatomic manipulation to influence pharyngeal mechanics. We have developed a two-dimensional computational model of the normal human upper airway based on signal averaging of MRI Using the finite element method, we can perform various anatomic perturbations on the structure in order to assess the impact of these manipulations on pharyngeal mechanics and collapse. By design, the normal sleeping upper airway model collapses at - 13 cm H2O. This closing pressure becomes more negative (ie, less collapsible) when we perform mandibular advancement (- 21 cm H2O), palatal resection (- 18 cm H2O), or palatal stiffening (- 17 cm H2O). Where clinical data are available in the literature, the results of our model correspond reasonably well. Furthermore, our model provides information regarding the site of, hypotheses for clinical studies that can he undertaken in the future (eg, obstruction and provides by combination therapies). We believe that, in the future, finite element modeling will provide a useful tool to help advance our understanding of OSA and its response to various therapies.
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