期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 17, 页码 3900-3907出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.05.090
关键词
PDE5 inhibition; heterocycles
Several different heterocyclic systems were compared as PDE5 inhibitor scaffolds. In addition to the known 3H-imidazo [5,1 -f][ 1, 2,4]triazin-4-ones and pyrazolopyrimidinones, isomeric imidazo[1,5-a][1,3,5]triazin-4(3H)-ones were also shown to be potent and selective PDE inhibitor scaffolds with in vivo activity. SAR trends were elucidated for sulfonamide derivatives with generality across different scaffolds. (c) 2005 Elsevier Ltd. All rights reserved.
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