期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 20, 期 9, 页码 809-815出版社
WILEY
DOI: 10.1002/gps.1361
关键词
autobiographical memory; Alzheimer's disease; semantic dementia; frontotemporal dementia
资金
- NIA NIH HHS [P01 AG019724, 5P01 AG 19724-02] Funding Source: Medline
Background Several studies have found impaired recall of remote autobiographical memories relative to recent memories in semantic dementia (SD), a pattern opposite to that in Alzheimer's disease (AD). Objective To document dissociation of memory for autobiographical incidents and personal semantic information in individuals with AD, frontotemporal dementia (FTD), and SD. Methods The authors administered the Autobiographical Memory Interview to eight individuals with AD, 11 with FrD, eight with SD, and eight normal controls. Autobiographical incidents and personal semantic memory was assessed from three time periods: childhood, early adulthood, and recent life. Results Individuals with SD recalled more details of autobiographical incidents from the most recent 5 years than from childhood and early adulthood (childhood vs recent life: t(7) = -3.59, p = 0.009; early adulthood vs recent life: t(7) = -4.33, p = 0.003). No difference was found between childhood and early adulthood (t(7) = 1.11, p = 0.305). Recall of personal semantic information was related to the age of the memory with less remembered from earlier time periods (childhood vs recent life: t(7) = -6.52, p < 0.001; childhood vs early adulthood: t(7) = -2.61, p = 0.035; early adulthood vs recent life: t(7) = -9.15, p < 0.001): Conclusions SD is a compelling model in which to study the anatomy of episodic memory. Copyright (c) 2005 John Wiley & Sons, Ltd.
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