期刊
JOURNAL OF CRITICAL CARE
卷 20, 期 3, 页码 239-249出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.jcrc.2005.03.003
关键词
cost-effectiveness; Pentaglobin; severe sepsis; septic shock
Purpose: To measure the cost-effectiveness of a specific polyclonal intravenous immune globulin preparation (Pentaglobin) in adult patients treated for severe sepsis and septic shock. Materials and Methods: Effectiveness data from a meta-analysis of 9 randomized trials (N = 435) were used to populate a decision model to estimate the cost-effectiveness of Pentaglobin and its comparator standard therapy from the hospital perspective in Germany. Primary outcome: all-cause morality; secondary outcome: intensive care unit (ICU) length of stay. Benefit was expressed as lives saved (LS). Published cost data were applied to assess differences in ICU treatment costs. Cost-effectiveness was calculated as incremental cost per LS. Results: Pentaglobin reduced the risk of mortality (P <.001) but had no effect on ICU length of stay. A baseline risk of mortality of 0.4434 (risk ratio = 0.5652; absolute risk reduction = 0.1928; number-needed-to-treat = 5.19) increased ICU treatment costs with Pentaglobin by euro2037 (euro22711 vs euro24747) with a cost per LS of euro10565. Sensitivity analyses on baseline mortality risk (95% confidence interval 0.3293-0.5162) and risk ratio (95% confidence interval 0.4306-0.7420) yielded a cost per LS range of euro5715 to euro28443 with a 56.3% probability of cost-effectiveness of euro12 000 or less. Conclusions: Pentaglobin is a promising adjuvant therapy both clinically and economically for treatment of adults with severe sepsis and septic shock. (c) 2005 Elsevier Inc. All rights reserved.
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