期刊
NATURE NEUROSCIENCE
卷 8, 期 9, 页码 1142-1144出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1517
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资金
- NHLBI NIH HHS [R01 HL070029, R01 HL070029-02, HL70029] Funding Source: Medline
Ablation of preBotzinger complex (preBotC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBotC neurons and could underlie death during sleep in these populations.
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