期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 289, 期 3, 页码 H1153-H1160出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00048.2005
关键词
erb-b2; neuregulin; conditional knockout; mouse; heart
资金
- FIC NIH HHS [R03 TW-01152-03] Funding Source: Medline
- NHLBI NIH HHS [R01 HL066100] Funding Source: Medline
- CIT NIH HHS [PICT01-08291] Funding Source: Medline
The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function.
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