期刊
MOVEMENT DISORDERS
卷 20, 期 9, 页码 1191-1194出版社
WILEY
DOI: 10.1002/mds.20504
关键词
alpha-synuclein; Parkinson's disease; silent mutation; mutational screening
资金
- NCRR NIH HHS [M01-RR00052] Funding Source: Medline
- NINDS NIH HHS [P50-NS38377] Funding Source: Medline
Data on the frequency of a-synuclein mutations in Parkinson's disease (PD) are limited. Screening the entire coding region in 1,921 PD patients with denaturing high performance liquid chromatography and subsequent sequencing we only detected silent mutations (g.2654A>G, g.10151G>A, and g.15986A>T) and the c.209G> A substitution corresponding to the p.A53T mutation. These results demonstrate that mutations in the a-synuclein gene are rare and suggest that other factors contribute to alpha-synuclein aggregation in the majority of PD patients. (C) 2005 Movement Disorder Society.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据