期刊
BIOSYSTEMS
卷 81, 期 3, 页码 267-280出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2005.05.004
关键词
temperature effects; Hodgkin-Huxley model; coherence resonance
Based on the Hodgkin-Huxley (HH) model, the effects of patch temperature as a control parameter on the spontaneous action potentials for finite size of membrane patch are studied. With increasing patch temperature, it is found that the mean open rates of sodium and potassium channels of the HH neuron are decreased, and the mean duration of spikes of membrane potential is also decreased, which are qualitatively consistent with previous experimental results of single ion channel. Under moderate patch size, the mean interspike interval of membrane potential first decreases, reaches a minimum, and then increases with increasing patch temperature. It is shown that for both low and high temperatures, the channels fluctuation-induced spontaneous action potentials appear to be rather irregular, while for moderate patch temperature, relatively coherent oscillations observed. By defining a measure parameter, we show that there is a maximal region for the measure P in the patch temperature and patch size parameter plane where the coherence resonance phenomena are very remarkable, and the characteristic correlation time of the output also confirm our result. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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