期刊
NEUROSCIENCE LETTERS
卷 386, 期 1, 页码 18-22出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.05.049
关键词
glutamate transporters; GLAST; GLT-1; astrocytes; hyperalgesia; pain; chemotherapy; paclitaxel
资金
- NINDS NIH HHS [NS-39933] Funding Source: Medline
Changes in the expression of glial glutamate transporters (GLAST and GLT-1) were examined in the spinal cord of rats with chemotherapy (taxol)-induced mechanical hyperalgesia. Immunohistochemical studies show that the expression of both GLAST and GLT-1 in the L4-L5 spinal dorsal horn is decreased by 24% (P < 0.001) and 23% (P < 0.001), respectively, in rats with taxol-induced hyperalgesia as compared with those in control rats. These changes were further confirmed using an enzyme-linked immunosorbent assay that confirmed downregulation of GLAST by 36% (P < 0.05) and GLT-1 by 18% (P < 0.05) in the L4-L5 spinal cord of taxol-treated rats. These data indicate that downregulation of glutamate transporters may contribute to the development of hyperalgesia induced by taxol and suggest. that glutamate transporters may be a new target for treatment of pain. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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