4.8 Article

Chip-based Microelectrodes for detection of single-nucleotide mismatch

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ANALYTICAL CHEMISTRY
卷 77, 期 17, 页码 5766-5769

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AMER CHEMICAL SOC
DOI: 10.1021/ac050741o

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Microelectrode arrays having eight 10-mu m-diameter gold microelectrodes arranged on a gold-covered Si chip were designed and characterized. The chips prove useful for the detection of single-nucleotide mismatches in unlabeled and prehybridized DNA by electrochemical impedance spectroscopy.

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