期刊
NATURE CELL BIOLOGY
卷 7, 期 9, 页码 870-U16出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1288
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资金
- NCI NIH HHS [R01 CA095287, P01 CA72006, R01 CA099948, R01 CA95287, R01 CA095287-05, R01 CA109390-01, P01 CA072006-07, R01 CA99948, R01 CA109390, P01 CA072006] Funding Source: Medline
- NHLBI NIH HHS [T32 HL007731, 5T32HL007731] Funding Source: Medline
The microvasculature consists of endothelial cells and their surrounding pericytes. Few studies on the regulatory mechanisms of tumour angiogenesis have focused on pericytes. Here we report the identification of tumour- derived PDGFR beta(+) ( platelet- derived growth factor receptor beta) progenitor perivascular cells ( PPCs) that have the ability to differentiate into pericytes and regulate vessel stability and vascular survival in tumours. A subset of PDGFR beta(+) PPCs is recruited from bone marrow to perivascular sites in tumours. Specific inhibition of PDGFR beta signalling eliminates PDGFR beta(+) PPCs and mature pericytes around tumour vessels, leading to vascular hyperdilation and endothelial cell apoptosis in pancreatic islet tumours of transgenic Rip1Tag2 mice.
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