期刊
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
卷 84, 期 2, 页码 269-280出版社
SOC EXP ANALYSIS BEHAVIOR INC
DOI: 10.1901/jeab.2005.99-04
关键词
cocaine self-administration; delayed reinforcement; acquisition; lever press; rhesus monkey
资金
- NIDA NIH HHS [DA01961, K21 DA000254, R01 DA009161, P01 DA000254, DA00254, P50 DA000254] Funding Source: Medline
- PHS HHS [F007190] Funding Source: Medline
Six experimentally naive rhesus monkeys produced 0.01 mg/kg/infusion cocaine by lever pressing under a tandem fixed-ratio 1 differential-reinforcement-of-other-behavior schedule. One lever press initiated an unsignaled 15- or 30-s delay culminating in cocaine delivery. Each press made during the delay reset the delay interval. With two exceptions, responding was acquired and maintained at higher rates than responding on a second (inoperative) lever. For the exceptions, a cancellation contingency was arranged in which each formerly inoperative-lever response reset the tandem schedule. This manipulation reduced presses on the inoperative lever. Subsequently, the consequences of responding on the two levers were reversed, and the monkeys again responded at higher rates on the operative lever. As a comparison, 3 additional experimentally naive monkeys received response-independent cocaine deliveries. Although lever pressing was observed, it extinguished and was subsequently reestablished under the tandem schedule. The results suggest that although response-reinforcer contiguity is not required for cocaine to acquire reinforcing functions, a response-re in forcer relation appears necessary.
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