期刊
DEVELOPMENTAL CELL
卷 9, 期 3, 页码 403-414出版社
CELL PRESS
DOI: 10.1016/j.devcel.2005.07.009
关键词
-
资金
- NIGMS NIH HHS [GM34028, GM067031, 5F32GM065721-02, F32 GM065721, R01 GM067031, F32 GM065721-03, R01 GM034028] Funding Source: Medline
The microRNA let-7 is a critical regulator of developmental timing events at the larval-to-adult transition in C. elegans. Recently, microRNAs with sequence similarity to let-7 have been identified. We find that doubly mutant animals lacking the let-7family microRNA genes mir-48 and mir-84 exhibit retarded molting behavior and retarded adult gene expression in the hypodermis. Triply mutant animals lacking mir-48, mir-84, and mir-241 exhibit repetition of L2-stage events in addition to retarded adult-stage events. mir-48, mir-84, and mir-241 function together to control the L2-to-L3 transition, likely by base pairing to complementary sites in the hbi-13 ' UTR and downregulating hbi-1 activity. Genetic analysis indicates that mir-48, mir-84, and mir-241 specify the timing of the L2-to-L3 transition in parallel to the heterochronic genes lin-28 and lin-46. These results indicate that let-7family microRNAs function in combination to affect both early and late developmental timing decisions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据