期刊
JOURNAL OF DERMATOLOGICAL SCIENCE
卷 39, 期 3, 页码 147-154出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jdermsci.2005.03.010
关键词
androgenic alopecia; bulge; cytokeratin15; proteoglycans; stem cells
类别
Background: Versican, a large chondroitin sulfate proteogtycan molecule, is implicated in the induction of hair morphogenesis, the initiation of hair regeneration, and the maintenance of hair growth in mouse species. In contrast, in human hair follicles, the distribution and the roles of versican remains obscure. Objectives: To elucidate the implication of versican in normal human hair growth. Methods: Versican expression was examined by in situ hybridization (mRNA) and immunohistochemistry (protein). Results: The results clearly showed specific versican gene expression in the dermal papilla of anagen, which apparently decreased in the dermal papilla of catagen hair follicles. No specific signal was detectable in telogen hair follicles. Consistent with ISH results, versican immunoreactivity was extended over the dermal papilla of anagen hair follicles, and again, this staining diminished in the catagen phase of human hair follicles. Interestingly, versican proteins were deposited outside K15-positive epithelial cells in the bulge throughout the hair cycle. Versican immunoreactivity in the dermal papilla was almost lost in vellus-tike hair follicles affected by mate pattern baldness. Conclusion: Specific expression of versican in the anagen hair follicles suggests its importance to maintain the normal growing phase of human as well as mouse. (c) 2005 Japanese Society for Investigative Dermatology. Elsevier Ireland Ltd. All rights reserved.
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